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Published Studies on Autism

Published studies on Autism


Neurodevelopmental disorders, maternal Rh-negativity, and Rho(D) immune globulins: a multi-center assessment

Geier 2007

"Results: There were significant and comparable increases in maternal Rh-negativity among children with Neurodevelopmental disorders, (Clinic: A=24.2%), autism spectrum disorders (Clinic: A=28.3%, B=25.3%), and attention-deficit-disorder/attention-deficit-hyperactivity-disorder (Clinic: A=26.3%) observed at both clinics in comparison to both control groups (Clinic: A=12.1%, B=13.9%) employed. Children with NDs born post-2001 had a maternal Rh-negativity frequency (13.6%) similar to controls."

The results show that prior to 2001 there was a significant number of kids who had autism who's mothers received Rhogam shot while pregnant compared to those who did not receive Rhogam shot.

However, after 2001 there is no longer a significant difference in mothers who did verses did not receive a Rhogam shot.

The difference they highlight is that the Rhogam shot was reformulated in 2001 to remove the ingredient Thimerisol.


Neurodevelopmental disorders following thimerosal-containing childhood immunizations: a follow-up analysis

David Geier et al. Int J Toxicol. Nov-Dec 2004.

"It was determined that there were significantly increased odds ratios (ORs) for autism (OR = 1.8, p < .05), mental retardation (OR = 2.6, p < .002), speech disorder (OR = 2.1, p < .02), personality disorders (OR = 2.6, p < .01), and thinking abnormality (OR = 8.2, p < .01) adverse events reported to the VAERS following thimerosal-containing DTaP vaccines in comparison to thimerosal-free DTaP vaccines."

A positive association found between autism prevalence and childhood vaccination uptake across the U.S. population

Gayle Delong. J Toxicol Environ Health A. 2011.

"A positive and statistically significant relationship was found: The higher the proportion of children receiving recommended vaccinations, the higher was the prevalence of AUT or SLI. A 1% increase in vaccination was associated with an additional 680 children having AUT or SLI."

The association between mercury levels and autism spectrum disorders: A systematic review and meta-analysis

"Results of the current meta-analysis revealed that mercury is an important causal factor in the etiology of ASD. It seems that the detoxificationand excretory mechanisms are impaired in ASD patients which lead to accumulation of mercury in the body. Future additional studies on mercury levels in different tissues of ASD patients should be undertaken."

Thimerosal: Clinical, epidemiologic and biochemical studies

"July 7, 1999, the US Public Health Service (USPHS) and American Academy of Pediatric (AAP) called for the elimination of Thimerosal from all vaccines in the US as soon as possible. As more of the reduced-Thimerosal and no-Thimerosal vaccines became available in the early 2000s in the US, the assumption was that the exposure to Thimerosal would sharply decrease. However, this expecttion proved to not be accurate because of recommendation changes in the vaccination schedule. Therefore, the approximate maximum lifetime exposure to Hg from Thimerosal-preserved vaccines has increased compared to the lifetime exposure under the US CDC's pre-2000 recommended vaccination schedule. It is estimated that it is now more than double what it would have been had the pre-2000 vaccination schedule been maintained."

"Conclusion: The culmination of the research that examines the effects of Thimerosal in humans indicates that it is a poison at minute levels with a plethora of deleterious consequences, even at the levels currently administered in vaccines"


Toxic Heavy Metals and Autism Spectrum Disorder; Is There a Link???!!!

"They concluded that the limited ability of autistics to excrete heavy metals as well as the increased environmental exposure at key points of fetal and infantile development seems to have a significant role in the occurrence of ASD."
"Autistic children are defective in metabolizing sulfur compounds which results in significant reduction of their abilities to detoxify heavy metals and increases their toxicity. Also, they have impaired methylation and redox homeostasis with increased vulnerability to oxidative stress; like what occurs in cases of exposure to heavy metals intoxication, with subsequent negative impact on the development of the brain and normal CNS functions [6]."


Hair mercury in breast-fed infants exposed to thimerosal-preserved vaccines



" Overall, sensitivity w a s found to be 72% to 100% across Forms while specificity ranged from 73%to 100%.The findings suggests that the use of the cutoffs identified in this study greatly improves the value of the Brigance in the early detection of children with developmental problems."


Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure

"Our results provide strong evidence supporting a link between autism and the aluminum in vaccines "
"we identify several signs and symptoms that are significantly more prevalent in vaccine reports after 2000, including cellulitis, seizure, depression, fatigue, pain and death, which are also significantly associated with aluminum-containing vaccines."
"A meta-study involving oxidative-stress related biomarkers present in association with autism identified a consistent deficiency in reduced glutathione [17], an important sulfur-based antioxidant that also plays a role in detoxifying aluminum."
"Glutathione [23] and sulfate [24] are also essential for the detoxification of xenobiotics and commonly administered drugs like acetaminophen in the liver. Selenium, a trace metal in the same column of the periodic table as oxygen and sulfur, has been shown to protect against acetaminophen toxicity [25], and it has also been shown to be severely depleted in hair and nail samples from individuals on the autism spectrum [26]."
"It has recently been proposed that aluminum, commonly used in vaccines as an adjuvant, may be the most significant factor in adverse reactions, and, furthermore, that the nervous system is especially vulnerable to aluminum toxicity [45]. Vaccine clinical trials often include aluminum in the placebo, at the same or greater concentrations than the amount found in the vaccine [46–49]."
"The Food and Drug Administration (FDA) has set an upper limit of 5 micrograms Al/kg/day for neonates and individuals with impaired kidney function [51]. children today receive a cumulative aluminum burden from vaccines that may exceed the FDA limit by a factor of 50."


The Relationship Between the Level of Copper, Lead, Mercury and Autism Disorders: A Meta-Analysis

"There is, nevertheless, a significant relationship between mercury concentration and autism. Thus, the concentration of mercury can be listed as a pathogenic cause (disease-causing) for autism."

Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: A possible role of fluoride and aluminum

"Studies of autistic patients have confirmed the presence of a number of immune dysfunctions"
"Importantly, this research indicates that ASD children experience increase reactiveness of their peripheral immune system to immune activation and that they also experience priming and activation of their brain microglia in conjunction with systemic immune activation."
"Prolonged and repeated systemic immune activation appears to be central to ASD etiopathology. With subsequent, especially closely spaced immune stimulation, full activation of the overactive primed microglia occurs, leading to progressive pathological changes in the developing brain. This is especially so if the episodes of systemic immune stimulation are closely spaced together."
"Many investigations show that Al3+ can elicit impairment of development and immunity; that it acts as a hormonal disruptor, a neurotoxin, and elicits intense and prolonged activation of brain inflammation."
"In an extensive review, Tomljenovic and Shaw pointed out that 18 Al3+-containing adjuvanted vaccines are included in the current pediatric vaccine schedule.[256] They found that (1) children from countries with the highest ASD incidence appear to have the highest exposure to Al3+ from vaccines; (2) the increase in exposure to Al3+- adjuvants significantly correlates with increase ASD in the United States over the last two decades; and (3) a significant correlation exist between the amounts of Al3+ administered to preschool children and the current prevalence of ASD in seven Western countries, particularly at 3-4 months of age. The data satisfied Hill's criteria for causation."


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