Of the 621 people who contracted the illness, 85 percent had all their preventative shots — calling into question the efficacy of the vaccine.

Multiple studies demonstrate that 2–10% of those immunized with two doses of measles vaccine fail to develop protective antibody levels, and that immunity can wane over time and result in infection (so-called secondary vaccine failure) when the individual is exposed to measles. In an October 2011 outbreak in Canada, over 50% of the 98 individuals had received two doses of measles vaccine.

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-Nearly 200 people have contracted mumps at detention facilities across Texas since October, according to a state health agency. - “there has been no reported transmission to the community.” -She added that the state doesn’t know the vaccination status of detained migrant adults or the children who entered the U.S. with them but that “all unaccompanied minors are vaccinated when they are detained.”

In the last 13 years, major pertussis epidemics have occurred in the United States, and numerous studies have shown the deficiencies of DTaP vaccines, including the small number of antigens that the vaccines contain and the type of cellular immune response that they elicit. The type of cellular response a predominantly, T2 response results in less efficacy and shorter duration of protection. Because of the small number of antigens (3-5 in DTaP vaccines vs >3000 in DTwP vaccines), linked-epitope suppression occurs. Because of linked-epitope suppression, all children who were primed by DTaP vaccines will be more susceptible to pertussis throughout their lifetimes, and there is no easy way to decrease this increased lifetime susceptibility.

“The child is vaccinated, did not have any serious complications, and is fully recovered from the disease,”

-From 1985 through 1988, 68% of cases in school-aged children (age 5 to 19 years) occurred among those who had been appropriately vaccinated -In 2019, 13 outbreaks of measles were reported, accounting for 663 cases; six were associated with underimmunized close-knit communities -The original Edmonston B vaccine was withdrawn in 1975 because of a relatively high frequency of fever and rash in recipients. -Approximately 2% to 7% of children who receive only 1 dose of MMR vaccine fail to respond to it, i.e., they experience primary vaccine failure. MMR vaccine failure can occur because of passive antibody in the vaccine recipient, immaturity of the immune system, damaged vaccine, or other reasons. -Most adverse events reported following MMR vaccination (such as fever and rash) are attributable to the measles component. - “During the 1989 -1991 measles resurgence, incidence rates for infants were more than twice as high as those in any other age group. The mothers of many infants who developed measles were young, and their measles immunity was most often due to vaccination rather than infection with wild virus. As a result, a smaller amount of antibody was transferred across the placenta to the fetus, compared with antibody transfer from mothers who had higher antibody titers resulting from wild-virus infection. The lower quantity of antibody [in the vaccine] resulted in immunity that waned more rapidly, making infants susceptible at a younger age than in the past.”

In conclusion, the preponderance of available evidence now suggests that the list of plausible explanations for the resurgence of pertussis in the aP vaccination era goes beyond the “poor persistence” and “waning efficacy” of these vaccines to include an additional and likely pivotal factor: “lack of sterilizing mucosal immunity”. the current burden of disease is not well explained by the disease that is observed but implies asymptomatic chains of transmission; aP vaccination, or passively acquired antibodies resulting from aP vaccination, prevents symptomatic disease in animals but does not block infections; transmission readily occurs between asymptomatic aP-vaccinated but infected animals to uninfected animals in close physical proximity;

The observed effectiveness of any MMR vaccination adjusted for age, sex and general practice was 69%. - Two doses of vaccine were more effective (88%) than a single dose (64%).

-27 sailors and Marines aboard the dock landing ship USS Fort McHenry have been diagnosed with parotitis, which the Navy described in a statement earlier this month as a "viral infection which has symptoms similar to mumps." -Viral parotitis is an infection of the saliva glands on either side of the face that's typically caused by the mumps. -“The Navy’s position is that vaccines are effective at reducing the incidence and severity of vaccine-preventable diseases,” BUMED told BI. Unfortunately, “the mumps portion of the measles, mumps, and rubella (MMR) vaccine is the least effective of the three components, providing 88% effectiveness after completion of the two dose series”